Collagen is one of the most abundant proteins in the human body and serves as the main structural protein of the extracellular matrix (ECM) in connective tissues such as ligaments, tendons, cartilage and skin. Collagen is continuously produced and replaced to combat the breakdown and loss of connective tissue from daily wear and tear, injury or disease. However, as we age, that natural regenerative ability diminishes and our bodies are able to produce less and less collagen. Thus, highly purified collagen extracted from animal tissues in its native state can be used in clinical applications and in various formulations to replace the body’s native collagen.

Collagen serves several functions in the human body, maintainig the integrity and elasticity of the body’s connective tissues and thus supporting the form and function of the skin, cartilage and bones. The protein exists in a triple-helix formation that confers the necessary mechanical resistance to tensile forces and provides the capacity to bind a variety of macromolecules that form the extracellular matrix network. It is naturally assembled in several configurations, ranging from networks to fibrils, all of which serve various structural, mechanical and organizational roles to define local tissue architecture and influence cellular behavior.

Acid extraction processes can be used to produce collagen from animal tissue maintaining the telopeptide ends of the collagen chains. Enzyme-based extraction can remove the telopeptides resulting in atelocollagen that exhibits reduced immunogenicity.


Research Applications

Collagen is used in research to create gels for cell culture, scaffolds for tissue engineering and in assays that study cell behavior and cellular interactions with the extracellular environment
  • in vitro assays
  • tissue engineering/ regenerative medicine
  • in vivo studies

Cosmeceuticals & Nutraceuticals

Collagen and collagen peptides are major components of high-end skincare products and nutraceuticals for skin and joint health
  • cosmeceutical
  • nutraceuticals and nutricosmetics

Medical Applications

Collagen scaffolds, coatings, implants and fillers can be used in clinical practice for skin regeneration, in wound care products and in surgical, dental, and orthopedic applications.
  • wound care
  • dermatological/skin regeneration
  • other medical (dental, orthopedic, surgical)



  • Proprietary extraction methods leading to superior yields of Type I atelocollagen and telocollagen forms that maintain the triple helical structure and fibrillar nature of collagen
  • Extraction process preserves the structural and mechanical properties of the native protein found in tissue (strength, elasticity, etc)
  • Enzyme treatment and dialysis purification lead to highly purified atelocollagen products through the complete removal of degradation byproducts and impurities
  • Chemically and thermally stable products, provided in lyophilized form to remove water content, allowing for an extended shelf life
  • Atelocollagen products with enhanced biocompatibility/biodegradability and low antigenicity
  • Custom formulations developed according to strict customer specifications
Lyophilized collagen - exhibits structural rigidity and stability
Collagen for gel formation, ideal for cell culture
Collagen fibrils retain mechanical strength and elasticity
Pore sizes ideal for tissue engineering and drug delivery


  • Collagen extracted from EU-sourced porcine tissues, with negligible BSE risk and from veterinary-controlled herds
  • Extraction process utilizing collagen-rich tissues such as tendons (no skin or bone tissue) that results in highly pure Type I collagen products
  • Production facilities operating under strict EU controls and regulations, with GMP-compliance and ISO certification in progress
  • Extensive microbiological testing and analysis at all stages of extraction
  • Collagen quality & purity assessed and quantified via SDS-Page and amino acid analysis
  • Biomechanical parameters and properties (stiffness, tensile strength) assessed in state-of-the-art university research facilities


Figure shows highly purified atelocollagen product, both in lyophilized form (A) and in solution (B), without the presence of other protein impurities or extraction by-products.

Representative images and data are the property of Promed Bioscience Ltd, and cannot be reproduced without the express permission of the company.


  • Company innovates to fulfill unmet market opportunities such as organic-sourced collagen products
  • Focus on unique consumer needs such as oncology patients who seek effective management of the side effects and complications caused by conventional cancer treatments (chemotherapy, radiation therapy)


  • Continuous investment in R&D to develop innovative collagen products and formulations
  • Highly scientific team with strong academic/research backgrounds and a recipient of multiple EU research grants to work on novel collagen applications
  • Collaboration with research and clinical institutions, providing additional resources and expertise to complement its core competencies
  • Company focus on innovation leads to higher yields and a very competitive cost structure